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AKAP6/FKBP1B/PKA catalytic/PP1/PP2A/PRKAR2A/RYR2
Function:
- may play a role folding of proteins via:
- cis-trans isomerization of proline
- release of Ca+2
Structure:
- subunits include:
- AKAP6, FKBP1B, PKA catalytic, PP1, PP2A, PRKAR2A, RYR2
General
molecular complex
Properties
SUBUNITS: A-kinase anchor protein 6
COMPARTMENT: cell nucleus
MOTIF: spectrin repeat {762-848}
spectrin repeat {1036-1150}
membrane region
serine-rich region {1560-1701}
MOTIF: serine residue (SEVERAL)
PKA-RII subunit binding {2063-2076}
FK506-binding protein 1B
COMPARTMENT: cytoplasm
MOTIF: active site
SITE: 19-107
cAMP kinase
COMPARTMENT: cytoplasm
MOTIF: S/T phosphorylation site
kinase domain
MOTIF: ATP-binding site
NAME: ATP-binding site
STATE: active state
phosphatase-1
COMPARTMENT: cell nucleus
STATE: active state
phosphatase-2A
COMPARTMENT: cell nucleus
cytoplasm
MOTIF: active site
Ser-phosphate (2)
STATE: active state
PKA2 regulatory-alpha
COMPARTMENT: cytoplasm
MOTIF: Dimerization and phosphorylation {2-138}
MOTIF: Thr phosphorylation site {T54}
Ser phosphorylation site {S58}
Ser phosphorylation site {S78}
Ser phosphorylation site {S80}
Ser phosphorylation site {S99}
cAMP-binding site
SITE: 139-260
MOTIF: cAMP-binding site
SITE: 208-208
cAMP-binding site
SITE: 217-217
cAMP-binding site
SITE: 261-404
MOTIF: cAMP-binding site
SITE: 338-338
cAMP-binding site
SITE: 347-347
ryanodine receptor 2
COMPARTMENT: cellular membrane
MOTIF: cytoplasmic domain {1-3087}
MOTIF: EF hand
SITE: 71-106
MIR 1 {108-163}
MIR 2 {170-215}
MIR 3 {223-278}
MIR 4 {284-341}
MIR 5 {349-406}
B30.2/SPRY 1 {597-807}
4 X approximate repeats {851-2923}
consensus repeat {851-964}
consensus repeat {965-1078}
B30.2/SPRY 2 {1023-1220}
B30.2/SPRY 3 {1335-1560}
Modulator {2616-3013}
consensus repeat {2690-2808}
binding site
SITE: 2772-2804
FOR-BINDING-OF: calmodulin
Ser phosphorylation site {S2806}
consensus repeat {2810-2923}
binding site
SITE: 2874-2895
FOR-BINDING-OF: calmodulin
binding site
SITE: 2995-3013
FOR-BINDING-OF: calmodulin
transmembrane domain {3088-3107}
exoplasmic loop {3108-3150}
transmembrane domain {3151-3169}
cytoplasmic loop {3170-3937}
MOTIF: N-glycosylation site {N3425}
N-glycosylation site {N3534}
N-glycosylation site {N3768}
N-glycosylation site {N3862}
N-glycosylation site {N3863}
N-glycosylation site {N3903}
transmembrane domain {3938-3957}
exoplasmic loop {3958-3975}
transmembrane domain {3976-3993}
cytoplasmic loop {3994-4230}
MOTIF: EF hand
SITE: 4021-4056
N-glycosylation site {N4073}
N-glycosylation site {N4102}
N-glycosylation site {N4109}
transmembrane domain {4231-4254}
exoplasmic loop {4255-4291}
transmembrane domain {4292-4312}
cytoplasmic loop {4313-4497}
MOTIF: coiled coil {4410-4443}
glutamate-rich region {4412-4453}
MOTIF: glutamate residue (SEVERAL)
transmembrane domain {4498-4518}
exoplasmic loop {4519-4575}
transmembrane domain {4576-4598}
cytoplasmic loop {4599-4717}
transmembrane domain {4718-4738}
exoplasmic loop {4739-4765}
transmembrane domain {4766-4784}
cytoplasmic loop {4785-4807}
MOTIF: N-glycosylation site {N4792}
transmembrane domain {4808-4825}
exoplasmic loop {4826-4842}
transmembrane domain {4843-4865}
cytoplasmic domain {4865-4965}
ION-PERMEABILITY: Ca+2
References
- UniProt :accession P68106
Components
A-kinase anchor protein 6; AKAP-6; A-kinase anchor protein 100 kD; AKAP 100; protein kinase A-anchoring protein 6; PRKA6; mAKAP (AKAP6 AKAP100 KIAA0311)
cAMP-dependent protein kinase catalytic subunit or protein kinase A [PKA] catalytic subunit
FK506-binding protein 1B (12.6 kD FK506-binding protein, immunophilin FKBP12.6, FKBP1B)
phosphatase-1 (PP1)
phosphatase-2A (ceramide-activated protein phosphatase)
protein kinase A2 [PKA2] regulatory subunit-alpha (PRKAR2A)
ryanodine receptor 2; RYR-2; RyR2; hRYR-2; cardiac muscle-type ryanodine receptor; cardiac muscle ryanodine receptor-Ca+2 release channel (RYR2)