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HIV1/AIDS-associated cardiac disease

Etiology: 1) dilated cardiomyopathy a) 10-20% of patients with AIDS b) 50% of autopies of patients dying from HIV infection c) cardiac opportunistic infection 1] toxoplasmosis 2] cytomegalovirus d) cardiac toxicity of pharmaceutical agents 1] zidovudine (AZT) 2] interferon-alpha 2A (Roferon-A) 2) atherosclerosis & coronary artery disease [1,3,4] - antiretroviral protease inhibitors are associated with hyperlipidemia [2,3]

Related

Acquired Immuno-Deficiency Syndrome (HIV infection stage 3, AIDS)

General

complications in patients with HIV1 infection heart disease (cardiac disease)

References

  1. Journal Watch 24(11):88-89, 2004 Hsue PY, Lo JC, Franklin A, Bolger AF, Martin JN, Deeks SG, Waters DD. Progression of atherosclerosis as assessed by carotid intima- media thickness in patients with HIV infection. Circulation. 2004 Apr 6;109(13):1603-8. Epub 2004 Mar 15. PMID: 15023877
  2. Farrugia PM, Lucariello R, Coppola JT. Human immunodeficiency virus and atherosclerosis. Cardiol Rev. 2009 Sep-Oct;17(5):211-5 PMID: 19690471
  3. Medical Knowledge Self Assessment Program (MKSAP) 16, 18. American College of Physicians, Philadelphia 2012, 2018
  4. Vachiat A, McCutcheon K, Tsabedze N, Zachariah D, Manga P. HIV and Ischemic Heart Disease. J Am Coll Cardiol. 2017 Jan 3;69(1):73-82. Review. PMID: 28057253 Free Article