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AI2CA

Classification as cytokine receptor & JAK-binding site inferred from homology with cytokine receptors.

Related

Janus kinase (JAK)

General

cytokine receptor oligomerizing protein

Properties

COMPARTMENT: plasma membrane MOTIF: cysteine residue {N-TERMINAL} (4) ligand-binding site WSXWS motif {W1} WSXWS motif {W2} transmembrane domain box1 motif FOR-BINDING-OF: Janus kinase (JAK) box2 motif FOR-BINDING-OF: Janus kinase (JAK) Tyr phosphorylation site cysteine residue {C-2} (4) binding site FOR-BINDING-OF: Janus kinase (JAK)

References

  1. Taga T & Kishimoto T Cytokine receptors and signal transduction FASEB J 6:3387 1992 PMID: 1334470
  2. Ihle JN et al Signaling by the cytokine receptor superfamily: JAKs and STATs TIBS 19:222 1994 PMID: 8048164