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AH receptor-interacting protein; AIP; aryl-hydrocarbon receptor-interacting protein; immunophilin homolog ARA9; HBV X-associated protein 2; XAP-2 (AIP, XAP2)
Function:
- positive role in AHR (aromatic hydrocarbon receptor) signaling (putative), possibly by influencing its receptivity for ligand &/or its nuclear targeting
- negative regulator of the hepatitis B virus (HBV) X protein
Structure:
- contains 1 PPIase FKBP-type domain
- contains 2 TPR repeats
Compartment: cytoplasm
Expression:
- widely expressed
- higher levels seen in the heart, placenta & skeletal muscle
- not expressed in the liver
Pathology:
- defects in AIP are a cause of
a) pituitary adenoma predisposition
b) familial isolated pituitary adenoma
c) growth hormone-secreting pituitary adenoma
d) ACTH-secreting pituitary adenoma
e) prolactin-secreting pituitary adenoma
General
carrier protein (transporter)
isomerase
phosphoprotein
Properties
SIZE: entity length = 330 aa
MW = 38 kD
COMPARTMENT: cytoplasm
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
active site
SITE: 31-121
tetratricopeptide repeat {179-212}
Tyr phosphorylation site {Y248}
tetratricopeptide repeat {265-298}
Database Correlations
OMIM correlations
MORBIDMAP 605555
UniProt O00170
Pfam PF00254
Entrez Gene 9049
Kegg hsa:9049
References
- UniProt :accession O00170
- GeneReviews
http://www.ncbi.nlm.nih.gov/sites/genetests/lab/gene/AIP