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aryl hydrocarbon [Ah] receptor complex
Function:
- binds to the XRE promoter region of genes it activates
- activates expression of multiple phase I & II xenobiotic chemical metabolizing enzyme genes including CYP1A1 gene
- mediates biochemical & toxic effects of halogenated aromatic hydrocarbons
- role in cell-cycle regulation
- likely to play a role in the development & maturation of many tissues
Structure:
- heterodimer of AHR & ARNT
General
molecular complex
Properties
SIZE: MW = 280 kD
COMPARTMENT: cytoplasm
SUBUNITS: aryl hydrocarbon receptor
MOTIF: DNA-binding motif
SITE: 13-40
helix-loop-helix
NAME: helix-loop-helix
SITE: 41-81
FOR-BINDING-VIA: helix-loop-helix
PAS domain {111-181}
PAS domain {275-342}
PAC domain {348-386}
glutamine-rich region {600-640}
MOTIF: glutamine residue (SEVERAL)
ligand-binding site
heat shock protein HSP 90-beta
MOTIF: Ser phosphorylation site {S226}
Ser phosphorylation site {S255}
Ser phosphorylation site {S261}
Thr phosphorylation site {T297}
Tyr phosphorylation site {Y305}
Ser phosphorylation site {S307}
Ser phosphorylation site {S452}
Tyr phosphorylation site {Y484}
Ser phosphorylation site {S532}
Ser phosphorylation site {S718}
aryl hydrocarbon receptor nuclear translocator
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Ser phosphorylation site {S77}
DNA-binding motif
SITE: 90-102
MOTIF: arginine-rich region {99-102}
MOTIF: arginine residue (SEVERAL)
helix-loop-helix
NAME: helix-loop-helix
SITE: 103-143
FOR-BINDING-VIA: helix-loop-helix
PAS domain {161-235}
PAS domain {349-419}
PAC domain {424-467}
glutamine-rich region {503-507}
MOTIF: glutamine residue (SEVERAL)
glutamine-rich region {710-769}
MOTIF: glutamine residue (SEVERAL)
serine-rich region {738-741}
MOTIF: serine residue (SEVERAL)
References
- Hoffman EC, Reyes H, Chu FF, Sander F, Conley LH, Brooks BA, Hankinson O.
Cloning of a factor required for activity of the Ah (dioxin) receptor.
Science. 1991 May 17;252(5008):954-8.
PMID: 1852076
Components
aryl hydrocarbon receptor nuclear translocator; ARNT protein; class E basic helix-loop-helix protein 2; bHLHe2; Dioxin receptor, nuclear translocator; hypoxia-inducible factor 1-beta; HIF-1-beta; HIF1-beta (ARNT, BHLHE2)
aryl hydrocarbon receptor; Ah receptor; AhR; dioxin receptor (AHR)
heat shock protein HSP 90-beta; HSP 90; HSP 84 (HSP90AB1, HSP90B, HSPC2, HSPCB)