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aryl hydrocarbon receptor; Ah receptor; AhR; dioxin receptor (AHR)
Function:
- ligand-activated transcriptional activator
- role in cell-cycle regulation
- likely to play a role in the development & maturation of many tissues
- binds to DNA as heterodimer with ARNT (Ah receptor complex)
- efficient DNA binding requires dimerization with another bHLH protein
- in the nucleus, heterodimer of AHR & ARNT
- interacts with coactivators including SRC-1, RIP140 & NOCA7, & with the corepressor SMRT
- interacts with NEDD8 & IVNS1ABP
- binds MYBBP1A (putative)
- interacts with HSP90
Structure:
- contains 1 basic helix-loop-helix (bHLH) domain
- contains 1 PAC domain (PAS-associated C-terminal domain)
- contains 2 PAS domains (PER-ARNT-SIM domains)
Compartment:
- cytoplasm. nucleus
- first cytoplasmic
- upon binding with ligand & interaction with a HSP90, it translocates to the nucleus
Expression:
- expressed in all tissues tested, including blood, brain, heart, kidney, liver, lung, pancreas & skeletal muscle
- induced or repressed by TGF-beta & dioxin (cell-type specific)
- repressed by cAMP, retinoic acid, & TPA
Pharmacology:
- aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells
Related
2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin TCDD)
AH receptor-interacting protein; AIP; aryl-hydrocarbon receptor-interacting protein; immunophilin homolog ARA9; HBV X-associated protein 2; XAP-2 (AIP, XAP2)
aryl hydrocarbon [Ah] receptor complex
General
basic helix loop helix (bHLH) family transcription factor
Properties
SIZE: entity length = 848 aa
MW = 96 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: DNA-binding motif
SITE: 13-40
helix-loop-helix
NAME: helix-loop-helix
SITE: 41-81
FOR-BINDING-VIA: helix-loop-helix
PAS domain {111-181}
PAS domain {275-342}
PAC domain {348-386}
glutamine-rich region {600-640}
MOTIF: glutamine residue (SEVERAL)
Database Correlations
OMIM 600253
UniProt P35869
PFAM correlations
Entrez Gene 196
Kegg hsa:196
References
- Hoffman EC et al
Cloning of a factor required for activity of the Ah (dioxin)
receptor.
Science. 1991 May 17;252(5008):954-8.
PMID: 1852076
- UniProt :accession P35869
- Boitano AE et al.
Aryl hydrocarbon receptor antagonists promote the expansion of
human hematopoietic stem cells.
Science 2010 Sep 10; 329:1345
PMID: 20688981
http://dx.doi.org/10.1126/science.1191536
- Sauvageau G and Humphries RK.
The blood stem cell Holy Grail?
Science 2010 Sep 10; 329:1291.
PMID: 20829472
http://dx.doi.org/10.1126/science.1195173
Component-of
aryl hydrocarbon [Ah] receptor complex