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age-related physiological changes

General 1) diminished ability to maintain homeostasis 2) stress-induced changes more marked than changes at rest 3) variability increases among individuals 4) body size & composition a) decreased lean/fat body ratio b) decreased height after age 30-40 c) increased weight up to age 50 in men, 60 in women, then a decline d) total body water decreases e) diminished bone mass & total body Ca+2 5) motor skills a) decreased walking (& running) speed b) decreased motor coordination c) increased reaction time 6) pharmacokinetics a) increased 1/2life of lipid-soluble drugs b) increased peak concentration of hydrophilic drugs c) increased time for drug clearance 7) nonlinear patterns occur in molecular markers of aging [14] - dysregulation occurs at ~44 & ~60 years of chronological age [14] - cardiovascular disease, lipid & alcohol metabolism changes at the 40-year transition - immune regulation & carbohydrate metabolism changes at the 60-year transition [14]

Related

aging biology of aging confounding factors in evaluation of age related changes

Useful

age-related endocrinopathy

Specific

age-associated changes in adipose tissue age-associated changes in cardiovascular function age-associated changes in hearing age-associated changes in hematologic function age-associated changes in hematopoiesis age-associated changes in immunity; immunosenescence age-associated changes in metabolism age-associated changes in pulmonary function age-associated changes in renal function age-associated changes in skeletal muscle age-associated changes in sleep age-associated changes in smell age-associated changes in teeth age-associated changes in temperature regulation age-associated changes in the autonomic nervous system age-associated changes in the central nervous system age-associated changes in the digestive system age-associated changes in the endocrine system age-associated changes in the eye age-associated changes in the peripheral nervous system age-associated changes in the reproductive system age-associated changes in the skeletal system age-associated changes in the urinary system age-associated changes in the vestibular system age-associated changes in thirst neuropsychiatric features of aging pharmacokinetics in the elderly skin aging (includes aging of skin appendages)

References

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  13. Manor B, Costa MD, Hu K et al Physiological complexity and system adaptability: evidence from postural control dynamics of older adults. J Appl Physiol (1985). 2010 Dec;109(6):1786-91. Epub 2010 Oct 14. PMID: 20947715
  14. Shen X, Wang C, Zhou X, Zhou W, Hornburg D, Wu S, Snyder MP. Nonlinear dynamics of multi-omics profiles during human aging. Nat Aging. 2024 Aug 14. PMID: 39143318 https://www.nature.com/articles/s43587-024-00692-2