afadin- & alpha-actinin-binding protein (ADIP, afadin DIL domain-interacting protein, SSX2-interacting protein, SSX2IP, KIAA0923)

Function: 1) component of an adhesion system 2) role in organization of homotypic, interneuronal & heterotypic cell-cell adherens junctions 3) may connect nectin-afadin & E-cadherin-catenin system through alpha-actinin 4) role in organization of actin cytoskeleton at adherens junctions through afadin & alpha-actinin 5) interacts with SSX2 & SSX3, not with SSX1 & SSX4 Structure: - both the N-terminal (1-79) & C-terminal(304-614) regions are required for interaction with SSX2 Compartment: - cell junction, adherens junction, nucleus - not found at cell-matrix adherens junctions Alternative splicing: named isoforms=2 Expression: - widely expressed - expressed in brain > kidney, testis, spinal cord,liver, heart, lung, skeletal muscle, ovary, fetal liver, fetal brain - little to no expression in pancreas, spleen - in brain, expressed in all regions, highest expression in amygdala - expressed in fetal tissues, mainly in liver & brain

General

cytoskeletal protein phosphoprotein

Properties

SIZE: MW = 71 kD entity length = 614 aa COMPARTMENT: cell nucleus MOTIF: coiled coil {131-227} coiled coil {266-293} MOTIF: Ser phosphorylation site {S293} Ser phosphorylation site {S325} coiled coil {374-460}

Database Correlations

OMIM 608690 UniProt Q9Y2D8

References

UniProt :accession Q9Y2D8