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protein AF-9; ALL1 fused gene from chromosome 9 protein; myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein; YEATS domain-containing protein 3 (MLLT3, AF9, YEATS3)
Function:
- interacts with BCOR
- interacts with CBX8
Structure: contains 1 YEATS domain
Compartment: nucleus (putative)
Pathology:
- chromosomal translocation t(9;11)(p22;q23) involving MLLT3 with MLL/HRX is associated with acute leukemias; the result is a rogue activator protein
Related
AF9 gene or MLLT3 gene
General
nuclear protein
phosphoprotein
Properties
SIZE: entity length = 568 aa
MW = 63 kD
COMPARTMENT: cell nucleus
MOTIF: YEATS {8-112}
serine-rich region {149-194}
MOTIF: serine residue (SEVERAL)
Ser phosphorylation site {S288}
Ser phosphorylation site {S294}
nuclear translocation signal {295-300}
aspartate residue {375}
serine-rich region {383-391}
MOTIF: serine residue (SEVERAL)
Ser phosphorylation site {S412}
Ser phosphorylation site {S419}
Ser phosphorylation site {S429}
proline-rich region
SITE: 466-469
MOTIF: proline residue (SEVERAL)
valine residue {481}
Ser phosphorylation site {S483}
Database Correlations
OMIM 159558
UniProt P42568
Pfam PF03366
Entrez Gene 4300
Kegg hsa:4300
References
- UniProt :accession P42568
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org/genes/AF9.html