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AF4 protein; ALL1-fused gene product from chromosome 4; AF4/FMR2 family member 1; proto-oncogene protein AF4; FEL protein (AFF1, AF4, FEL, MLLT2)

Compartment: nucleus Pathology: - chromosomal translocation t(4;11)(q21;q23) with MLL is associated with acute leukeuma; the result is a rogue activator protein

Related

AF4 gene or MLLT2 gene

General

phosphoprotein transcription factor (TF)

Properties

SIZE: MW = 131 kD entity length = 1210 aa COMPARTMENT: cell nucleus MOTIF: serine-rich region {483-492} MOTIF: serine residue (SEVERAL) Ser phosphorylation site {S588} Thr phosphorylation site {T766} serine-rich region {835-843} MOTIF: serine residue (SEVERAL) proline-rich region SITE: 866-869 MOTIF: proline residue (SEVERAL) serine-rich region {871-874} MOTIF: serine residue (SEVERAL)

Database Correlations

OMIM 159557 UniProt P51825 Pfam PF05110

References

  1. OMIM :accession 159557
  2. UniProt :accession P51825