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AF4/FMR2 family member 3 (protein LAF-4, lymphoid nuclear protein related to AF4, mllt2-related protein, AFF3, LAF4)
Function:
1) transcription activator (putative)
2) lymphoid development & oncogenesis (putative)
3) binds, in vitro, to double-stranded DNA
Compartment: nucleus
Expression:
- preferentially expressed in lymphoid tissues
- highest levels in thymus
General
DNA-binding protein
Properties
SIZE: MW = 134 kD
entity length = 1227 aa
COMPARTMENT: cell nucleus
MOTIF: serine-rich region {413-419}
MOTIF: serine residue (SEVERAL)
serine-rich region {422-432}
MOTIF: serine residue (SEVERAL)
serine-rich region {440-445}
MOTIF: serine residue (SEVERAL)
serine-rich region {670-679}
MOTIF: serine residue (SEVERAL)
Database Correlations
OMIM 601464
UniProt P51826
Pfam PF05110
References
- UniProt :accession P51826
- Atlas of Genetics and Cytogenetics in Oncology and Haematology
http://atlasgeneticsoncology.org/Genes/LAF4ID315.html