Search
Advillin (p92, AVIL)
Function:
- Ca+2-regulated actin-binding protein
Structure:
- belongs to the villin/gelsolin family
- contains 6 gelsolin-like repeats
- contains 1 HP (headpiece) domain
Expression:
- expressed in small intestine & colonic lining > thymus, prostate, testes, uterus
General
Ca+2 binding protein
cytoskeletal protein
Properties
SIZE: MW = 92 kD
entity length = 819 aa
COMPARTMENT: cytoplasm
MOTIF: Core {1-731}
MOTIF: Gelsolin-like {24-73}
Tyr phosphorylation site {Y85}
Polyphosphoinositide binding {109-116}
Polyphosphoinositide binding {135-143}
Gelsolin-like {145-185}
Gelsolin-like {262-306}
Gelsolin-like {403-454}
Gelsolin-like {525-565}
Ser phosphorylation site {S616}
Gelsolin-like {628-669}
Headpiece {731-819}
MOTIF: villin headpiece domain {753-819}
Tyr phosphorylation site {Y758}
Database Correlations
UniProt O75366
PFAM correlations
References
UniProt :accession O75366