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advanced sleep-phase syndrome; familial advanced sleep-phase syndrome (FASPS)

Epidemiology: - common in the elderly Pathology: - circadian rhythm sleep-wake disorder Genetics: - associated with defects in CSNK1D - associated with defecs in PER2 Clinical manifestations: 1) persistent early onset of sleep (8-9 PM) 2) early morning awakening (3-5 AM) 3) individuals are 'morning larks' with a 4 hours advance of the sleep, temperature & melatonin rhythms 4) early sleep patterns are not associated with shortened sleep duration - sleep duration > 7 hours Differential diagnosis: - depression Management: - reassurance & patient education - improved sleep hygiene may be beneficial a) systematic gradual advancement of bedtime b) bright light therapy early in the evening - typical indoor lighting is inadequate - sunlight or commercially available light box is needed

General

sleep disorder syndrome

Database Correlations

OMIM 604348

References

  1. UniProt :accession P48730
  2. OMIM :accession 604348
  3. UCLA Intensive Course in Geriatric Medicine & Board Review, Marina Del Ray, CA, Sept 12-15, 2001
  4. Geriatric Review Syllabus, 7th edition Parada JT et al (eds) American Geriatrics Society, 2010 - Geriatric Review Syllabus, 8th edition (GRS8) Durso SC and Sullivan GN (eds) American Geriatrics Society, 2013
  5. Barion A, Zee PC. A clinical approach to circadian rhythm sleep disorders. Sleep Med. 2007 Sep;8(6):566-77 PMID: 17395535
  6. Morgenthaler TI, Lee-Chiong T, Alessi C et al Practice parameters for the clinical evaluation and treatment of circadian rhythm sleep disorders. An American Academy of Sleep Medicine report. Sleep. 2007 Nov;30(11):1445-59. Review. PMID: 18041479
  7. Sack RL, Auckley D, Auger RR et al Circadian rhythm sleep disorders: part II, advanced sleep phase disorder, delayed sleep phase disorder, free-running disorder, and irregular sleep-wake rhythm. An American Academy of Sleep Medicine review. Sleep. 2007 Nov;30(11):1484-501. Review. PMID: 18041481
  8. Zee PC, Attarian H, Videnovic A. Circadian rhythm abnormalities. Continuum (Minneap Minn). 2013 Feb;19(1 Sleep Disorders):132-47. Review. PMID: 23385698 Free PMC Article
  9. Kim JH, Elkhadem AR, Duffy JF. Circadian Rhythm Sleep-Wake Disorders in Older Adults. Sleep Med Clin. 2022 Jun;17(2):241-252. PMID: 35659077 Free PMC article. Review.