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advanced glycosylation end product [AGE] receptor (AGER, RAGE)
Function:
- mediates interactions of advanced glycosylation end products (AGE)
- receptor for amyloid beta peptide
Structure:
- contains 2 Ig-like C2-type domain (immunoglobulin-like)
- contains 1 Ig-like V-type domain (immunoglobulin-like)
Compartment:
- isoform 1: cell membrane
- isoform 2: secreted
Alternative splicing: named isoforms=2
Expression:
- endothelial cells
- microglia also show strong expression of RAGE
Pathology:
- in Alzheimer's disease, RAGE expression is increased especially in neurons close to amyloid deposits & those containing neurofibrillary tangles
- RAGE binds to the amyloid beta-peptide
Interactions
molecular events
Related
advanced glycation endproduct (AGE) pigment
Alzheimer's disease (AD)
microglia (Hortega cell)
Useful
MAPK/MAK/MRK overlapping kinase; MOK protein kinase; renal tumor antigen 1; RAGE-1 (RAGE, MOK, RAGE1)
General
cell surface receptor
Properties
COMPARTMENT: plasma membrane
MOTIF: N-glycosylation site {N25}
immunoglobulin superfamily domain {31-106}
MOTIF: cysteine residue {C38}
MODIFICATION: cysteine residue {C99}
N-glycosylation site {N81}
cysteine residue {C99}
MODIFICATION: cysteine residue {C38}
cysteine residue {C144}
MODIFICATION: cysteine residue {C208}
cysteine residue {C208}
MODIFICATION: cysteine residue {C144}
immunoglobulin superfamily domain {252-308}
MOTIF: cysteine residue {C259}
MODIFICATION: cysteine residue {C301}
cysteine residue {C301}
MODIFICATION: cysteine residue {C259}
transmembrane domain {343-363}
cytoplasmic domain {364-404}
Database Correlations
OMIM 600214
UniProt Q15109
PFAM correlations
Entrez Gene 177
Kegg hsa:177
References
- UniProt :accession Q15109
- OMIM :accession 600214
- Yan SD, Chen X, Fu J, Chen M, Zhu H, Roher A, Slattery T,
Zhao L, Nagashima M, Morser J, Migheli A, Nawroth P, Stern D,
Schmidt AM.
RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's
disease.
Nature. 1996 Aug 22;382(6593):685-91.
PMID: 8751438