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adseverin; scinderin (SCIN, KIAA1905)
Function:
- Ca+2-dependent actin filament-severing protein
- remains tightly bound to barbed end of F-actin after severing filament
- presumed to have a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane
- in vitro, has barbed end capping & nucleating activities in the presence of Ca+2
Structure:
- belongs to the villin/gelsolin family
- contains 6 gelsolin-like repeats
Compartment: cytoplasm, cytoskeleton
Alternative splicing: named isoforms=2
Expression: expressed in secretory cells
Comparative biology:
- Severin in Dictostelium homolog
General
cytoskeletal protein
Properties
SIZE: entity length = 715 aa
MW = 80 kD
COMPARTMENT: cytoplasm
MOTIF: Actin-severing {1-363}
MOTIF: Gelsolin-like {27-76}
Tyr phosphorylation site {Y102}
Polyphosphoinositide binding {112-119}
Polyphosphoinositide binding {138-146}
Gelsolin-like {148-188}
Gelsolin-like {265-307}
Ca(2+)-dependent actin binding {364-715}
MOTIF: Gelsolin-like {398-451}
Gelsolin-like {523-564}
Tyr phosphorylation site {Y599}
Gelsolin-like {626-668}
Database Correlations
UniProt Q9Y6U3
Pfam PF00626
Entrez Gene 85477
Kegg hsa:85477
References
- UniProt :accession Q9Y6U3
- Stossel TP.
On the crawling of animal cells.
Science. 1993 May 21;260(5111):1086-94. Review.
PMID: 8493552