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adrenomedullin (ADM, AM, PAMP)
Function:
- potent hypotensive agent & vasodilatator
- control of fluid & electrolyte homeostasis
- in the kidney
- diuretic & natriuretic
- inhibits aldosterone secretion by direct adrenal actions
- in pituitary gland
- inhibits basal ACTH secretion
- appear to act in brain & pituitary gland to facilitate loss of plasma volume, contributing to hypotensive effect
Structure: belongs to the adrenomedullin family
Compartment: secreted
Expression:
- highest levels found in pheochromocytoma & adrenal medulla
- also found in lung, ventricle & kidney tissues
General
secreted protein
Properties
SIZE: entity length = 185 aa
MW = 20 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-21}
cysteine residue {C110}
MODIFICATION: cysteine residue {C115}
cysteine residue {C115}
MODIFICATION: cysteine residue {C110}
Database Correlations
OMIM 103275
UniProt P35318
Pfam PF00214
Entrez Gene 133
Kegg hsa:133
References
- UniProt :accession P35318
- NIEHS-SNPs
http://egp.gs.washington.edu/data/adm/