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adrenodoxin reductase (ferredoxin NADP reductase, FDXR)
Function:
- serves as the 1st electron transfer protein in all the mitochondrial P450 systems, including
a) cholesterol side chain cleavage in all steroidogenic tissues
b) steroid 11-beta hydroxylation in the adrenal cortex
c) 25-OH-vitamin D3-24 hydroxylation in the kidney
d) sterol C-27 hydroxylation in the liver
- receives electrons from NADPH
- steroid metabolism; cholesterol metabolism
- interacts directly with FDX1 (putative)
2 reduced ferredoxin + NADP+ 2 oxidized ferredoxin + NADPH
Cofactor: FAD
Structure:
- monomer
- belongs to the ferredoxin--NADP reductase family
Compartment: mitochondria matrix
Alternative splicing: named isoforms=2
Related
adrenodoxin, mitochondrial; adrenal ferredoxin; ferredoxin-1; hepatoredoxin (FDX1 ADX)
steroid biosynthesis
General
flavoprotein
mitochondrial membrane protein
oxidoreductase
Properties
SIZE: entity length = 491 aa
MW = 54 kD
COMPARTMENT: mitochondria
MOTIF: binding site
SITE: 49-49
FOR-BINDING-OF: FAD; via amide nitrogen
binding site
SITE: 69-69
FOR-BINDING-OF: FAD
binding site
SITE: 77-77
FOR-BINDING-OF: FAD; via amide nitrogen
binding site
SITE: 113-113
FOR-BINDING-OF: FAD; via amide nitrogen and carbonyl oxygen
cofactor-binding site [184-187]
COFACTOR-BOUND: NADP
cofactor-binding site [228-229]
COFACTOR-BOUND: NADP
cofactor-binding site [240-240]
COFACTOR-BOUND: NADP
binding site
SITE: 398-398
FOR-BINDING-OF: FAD; via amide nitrogen
cofactor-binding site [405-407]
COFACTOR-BOUND: flavin adenine dinucleotide
MOTIF: cofactor-binding site [405-405]
COFACTOR-BOUND: NADP
Database Correlations
OMIM 103270
UniProt P22570
Pfam PF07992
Kegg hsa:2232
ENZYME 1.18.1.2
References
- OMIM :accession 103270
- Williams Textbook of Endocrinology, 8th ed, JD Wilson
& DW Foster (eds), WB Saunders Co, Philadelphia PA,
1992, pg 495
Component-of
multienzyme complex