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adrenodoxin, mitochondrial; adrenal ferredoxin; ferredoxin-1; hepatoredoxin (FDX1 ADX)
Function:
- adrenal ferredoxin
- role in the synthesis of thyroid hormones
- serves as an electron transport intermediate for mitochondrial forms of cyt P450
- transfers electrons from adrenodoxin reductase to the cytochrome P450 catalyzing cholesterol side chain cleavage
Cofactor:
- binds 1 2Fe-2S cluster: redox potential: E(0) is -448 mV
Structure:
- belongs to the adrenodoxin/putidaredoxin family
- contains 1 2Fe-2S ferredoxin-type domain
Compartment: mitochondrial matrix
Related
adrenodoxin reductase (ferredoxin NADP reductase, FDXR)
steroid biosynthesis
General
carrier protein (transporter)
iron sulfur protein
Properties
SIZE: entity length = 184 aa
MW = 19 kD
COMPARTMENT: mitochondrial matrix
MOTIF: 2Fe-2S ferredoxin-type {67-171}
MOTIF: cofactor-binding site [106-106]
COFACTOR-BOUND: iron sulfur [FeS] cluster
cofactor-binding site [112-112]
COFACTOR-BOUND: iron sulfur [FeS] cluster
cofactor-binding site [115-115]
COFACTOR-BOUND: iron sulfur [FeS] cluster
cofactor-binding site [152-152]
COFACTOR-BOUND: iron sulfur [FeS] cluster
Database Correlations
OMIM 103260
UniProt P10109
Pfam PF00111
Entrez Gene 2230
Kegg hsa:2230
References
- OMIM :accession 103260
- UniProt :accession P10109
Component-of
multienzyme complex