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adrenocortical hyperplasia
Pathology:
1) adrenal glands are overall normal size & weight in most affected patients
2) multiple small yellow-to-dark brown nodules surrounded by a cortex with a uniform appearance
3) moderate diffuse cortical hyperplasia with mostly nonpigmented nodules, multiple capsular deficits & massive circumscribed & infiltrating extra-adrenal cortical excrescences with micronodules
4) adrenocortical hyperplasia may lead to Cushing syndrome
Genetics:
- associated with defects in PDE11A gene
General
endocrine disease