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adrenal cortical hyperplasia; hyperadrenocorticism

Etiology: - pituitary/hypothalamic based -> increased ACTH production - ectopic ACTH production - bronchial carcinoids & small cell carcinomas account for most cases - pancreatic endocrine neoplasms - medullary thyroid carcinoma - thymic carcinoids - pheochromocytoma Pathology: - hyperplasia may be diffuse or nodular - in macronodular hyperplasia, the adrenals together may weigh up to 180 gms - nodules may measure up to 4 cm in diameter Clinical manifestations: 1) Cushing's syndrome 2) Conn's syndrome 3) virilization 4) feminization Differential diagnosis: - adrenal cortical adenoma

Specific

congenital adrenal hyperplasia (21-hydroxlase deficiency)

General

adrenal gland disease

References

  1. Diagnostic Surgical Pathology. Sternberg ed. Lippincott, Williams & Wilkins, 3rd ed. 1999