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glucokinase, hexokinase-D or hexokinase-4
Function:
- catalyzes phosphorylation of D-glucose to D-glucose-6-phosphate using ADP as the phosphate donor
- GDP & CDP can replace ADP, but with reduced efficiency (putative)
- carbohydrate degradation; glycolysis
ADP + D-glucose = AMP + D-glucose-6-phosphate
Cofactor: binds 1 Mg+2 per subunit (putative)
Structure:
- monomer (putative)
- belongs to the ADP-dependent glucokinase family
- contains 1 ADPK (ADP-dependent kinase) domain
Compartment: secreted (putative)
Alternative splicing: named isoforms=6
General
glucokinase, hexokinase-D or hexokinase-4
secreted protein
Properties
SIZE: entity length = 497 aa
MW = 54 kD
COMPARTMENT: cytoplasm
CELL: hepatocyte
beta cell
WITHIN: islets of Langerhans
MOTIF: signal sequence {1-22}
ADPK {52-497}
MOTIF: Mg+2-binding site
SITE: 297-297
Mg+2-binding site
SITE: 328-328
aspartate residue {D481}
Mg+2-binding site
SITE: 481-481
Database Correlations
OMIM 611861
UniProt Q9BRR6
Pfam PF04587
Entrez Gene 83440
Kegg hsa:83440
ENZYME 2.7.1.147
References
UniProt :accession Q9BRR6