patatin-like phospholipase domain-containing protein 3; acylglycerol O-acyltransferase; adiponutrin; Ca+2-independent phospholipase A2-epsilon; iPLA2-epsilon (PNPLA3, ADPN, C22orf20)

Function: - multifunctional enzyme a) triacylglycerol lipase b) acylglycerol O-acyltransferase activities - glycerolipid metabolism; triacylglycerol degradation Structure: contains 1 patatin domain Compartment: - membrane - single-pass type 2 membrane protein Alternative splicing: named isoforms=2 Expression: - induced by changes in energy balance - down-regulated following very low-calorie diet - refeeding elevates the mRNA level Pathology: - genetic variations in PNPLA3 are a cause of susceptibility to non-alcoholic fatty liver disease type 1 Polymorphism: - polymorphic variation at position 148 influences insulin secretion & obesity - in obese subjects, body mass index & waist circumference are higher in carriers of the Ile-148 allele - the Ile-148 carriers also display decreased insulin secretion in response to oral glucose tolerance test - Met-148 allele carriers are seemingly more insulin resistant at a lower body mass index

General

acyltransferase multifunctional enzyme patatin-like phospholipase domain-containing protein (PNPLA) triglyceride lipase

Properties

SIZE: entity length = 481 aa MW = 53 kD COMPARTMENT: cellular membrane MOTIF: Patatin {10-179} MOTIF: transmembrane domain {42-62} GXSXG {45-49} serine residue {S47} N-glycosylation site {N89} N-glycosylation site {N280}

Database Correlations

OMIM correlations UniProt Q9NST1 Pfam PF01734 Entrez Gene 80339 Kegg hsa:80339 ENZYME 3.1.1.3

References

UniProt :accession Q9NST1