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adiponectin receptor protein 2 (progestin & adipoQ receptor family member 2, ADIPOR2, PAQR2)
Function:
1) receptor for globular & full-length adiponectin
2) role in metabolic pathways that regulate lipid metabolism, i.e. fatty acid oxidation
3) mediates increased AMPK, PPARA ligand activity, fatty acid oxidation & glucose uptake by adiponectin
Structure:
- may form homo & heteromultimers
- belongs to the ADIPOR family
Compartment: cell membrane & intracellular organelles
Expression:
- expressed in skeletal muscle, liver , placenta > brain, heart, colon, spleen, kidney, thymus, small intestine, peripheral blood leukocytes, lung
Related
adiponectin; 30 kD adipocyte complement-related protein; adipocyte complement-related 30 kD protein; ACRP30; adipocyte, C1q & collagen domain-containing protein; adipose most abundant gene transcript 1 protein; apM-1; Gelatin-binding protein (ADIPOQ, ACDC, ACRP30, APM1, GBP28)
General
progestin & adipoQ receptor (PAQR)
transmembrane 7c protein
Properties
SIZE: MW = 44 kD
entity length = 386 aa
COMPARTMENT: cellular membrane
MOTIF: cytoplasmic domain {1-147}
transmembrane domain {148-168}
exoplasmic loop {169-181}
transmembrane domain {182-202}
cytoplasmic loop {203-220}
transmembrane domain {221-241}
exoplasmic loop {242-245}
transmembrane domain {246-266}
cytoplasmic loop {267-278}
transmembrane domain {279-299}
exoplasmic loop {300-307}
transmembrane domain {308-328}
cytoplasmic loop {329-342}
transmembrane domain {343-363}
exoplasmic domain {364-386}
Database Correlations
OMIM 607946
UniProt Q86V24
Pfam PF03006
References
UniProt :accession Q86V24