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adiponectin receptor protein 1 (progestin & adipoQ receptor family member 1, ADIPOR1, PAQR1, CGI-45)
Function:
1) receptor for globular & full-length adiponectin
2) involved in metabolic pathways that regulate lipid metabolism, i.e. fatty acid oxidation
3) mediates increased AMPK, PPARA ligand activity, fatty acid oxidation & glucose uptake by adiponectin.
4) high-affinity receptor for globular adiponectin
5) low-affinity receptor for full-length adiponectin
6) forms homo & heteromultimers
Compartment:
- localized to the cell membrane & intracellular organelles
- widely expressed
- expressed in skeletal muscle > brain, heart, spleen, kidney, liver, placenta, lung, peripheral blood leukocytes > colon, thymus, small intestine
Related
adiponectin; 30 kD adipocyte complement-related protein; adipocyte complement-related 30 kD protein; ACRP30; adipocyte, C1q & collagen domain-containing protein; adipose most abundant gene transcript 1 protein; apM-1; Gelatin-binding protein (ADIPOQ, ACDC, ACRP30, APM1, GBP28)
General
progestin & adipoQ receptor (PAQR)
transmembrane 7c protein
Properties
SIZE: MW = 43 kD
entity length = 375 aa
COMPARTMENT: cellular membrane
MOTIF: cytoplasmic domain {1-136}
transmembrane domain {137-157}
exoplasmic loop {158-170}
transmembrane domain {171-191}
cytoplasmic loop {192-209}
transmembrane domain {210-230}
exoplasmic loop {231-235}
transmembrane domain {236-256}
cytoplasmic loop {257-267}
transmembrane domain {268-288}
exoplasmic loop {289-296}
transmembrane domain {297-317}
cytoplasmic loop {318-331}
transmembrane domain {332-352}
exoplasmic domain {353-375}
Database Correlations
OMIM 607945
UniProt Q96A54
Pfam PF03006
References
UniProt :accession Q96A54