adipogenesis regulatory factor; adipogenesis factor rich in obesity; adipose most abundant gene transcript 2 protein; adipose-specific protein 2; apM-2 (ADIRF AFRO APM2 C10orf116)

Function: - role in fat cell development - promotes adipogenic differentiation & stimulates transcription initiation of master adipogenesis factors like PPARG & CEBPA at early stages of preadipocyte differentiation Compartment: nucleus Expression: - expressed in adipose tissue (at protein level) - highly expressed in omental & subcutaneous adipose tissues - expressed in heart, cornea, liver, kidney & spleen - up-regulated during pre-adipocyte differentiation - up-regulated following DNA damage induced by UV irradiation Pharmacology: - overexpression confers resistance to the anticancer chemotherapeutic drug cisplatin

Properties

SIZE: entity length = 76 aa MW = 8 kD COMPARTMENT: cell nucleus

Database Correlations

UniProt Q15847 Entrez Gene 10974 Kegg hsa:10974

References

UniProt :accession Q15847