adipocyte-specific adhesion molecule (Coxsackie- & adenovirus receptor-like membrane protein, CAR-like membrane protein, ASAM, ACAM, CLMP, UNQ318/PRO363)

Function: - may be involved in the cell-cell adhesion - may play a role in adipocyte differentiation & development of obesity Structure: - contains 2 Ig-like C2-type domain (immunoglobulin-like) Compartment: cell junction, tight junction Expression: - predominantly expressed in epithelial cells within different tissues & in white adipose tissue - expressed in small intestine & placenta > heart, skeletal muscle, colon, spleen, kidney & lung > liver & peripheral blood leukocytes - up-regulated in mature adipocytes & adipocyte tissue of obese individuals

General

glycoprotein membrane protein

Properties

SIZE: MW = 41 kD entity length = 373 aa COMPARTMENT: cellular membrane MOTIF: signal sequence {1-18} immunoglobulin superfamily domain {19-127} MOTIF: cysteine residue {C35} MODIFICATION: cysteine residue {C111} N-glycosylation site {N74} cysteine residue {C111} MODIFICATION: cysteine residue {C35} immunoglobulin superfamily domain {135-224} MOTIF: cysteine residue {C153} MODIFICATION: cysteine residue {C208} N-glycosylation site {N197} cysteine residue {C208} MODIFICATION: cysteine residue {C153} transmembrane domain {236-256} glutamate-rich region {265-268} MOTIF: glutamate residue (SEVERAL) serine-rich region {288-314} MOTIF: serine residue (SEVERAL)

Database Correlations

UniProt Q9H6B4 PFAM correlations

References

UniProt :accession Q9H6B4