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adipocyte enhancer-binding protein 1 (AE-binding protein 1, aortic carboxypeptidase-like protein, AEBP1, ACLP)
Function:
- may positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation & reduced adipocyte differentiation
- may also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation & subsequent degradation of I-kappa-B-alpha (NFKBIA), leading to enhanced macrophage
- inflammatory responsiveness (putative)
- can act as a transcriptional repressor (putative)
- interacts with GNG5, NFKBIA, MAPK1, MAPK3 & PTEN
- may interact with calmodulin (putative)
- binds to DNA in vitro (putative)
- phosphorylated by MAPK1 in vitro (putative)
Structure:
- belongs to the peptidase M14 family
- protein has lost active site residues & Zn+2-binding sites & so is unlikely to be catalytically active
- contains 1 F5/8 type C domain
Compartment:
- isoform 1: secreted (putative)
- isoform 2: cytoplasm (probable), nucleus
Alternative splicing: named isoforms=2
Expression:
- expressed in osteoblast & visceral fat
General
glycoprotein
Properties
SIZE: entity length = 1158 aa
MW = 131 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: signal sequence {1-25}
proline-rich region
SITE: 47-326
MOTIF: proline residue (SEVERAL)
coagulation factors 5/8 type C domain (FA58C) {383-540}
binding site
SITE: 390-555
FOR-BINDING-OF: REQUIRED FOR DNA
MAPK1 & MAPK3 interaction {421-624}
MOTIF: N-glycosylation site {N528}
PTEN interaction {555-985}
silencer element
SITE: 941-1158
MOTIF: MAPK1/MAPK3 interaction {1006-1158}
glutamate-rich region {1079-1136}
MOTIF: glutamate residue (SEVERAL)
Database Correlations
OMIM 602981
UniProt Q8IUX7
PFAM correlations
Kegg hsa:165
References
UniProt :accession Q8IUX7