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adenyl cyclase-9 (ATP pyrophosphate-lyase 9, ADCY9, KIAA0520)
Function:
- may play a fundamental role in situations where fine interplay between intracellular Ca+2 & cAMP determines cellular function
- may be a physiologically relevant docking site for calcineurin (putative)
- insensitive to Ca+2/calmodulin, forskolin & somatostatin
- stimulated by beta-adrenergic receptor activation
ATP 3',5'-cyclic AMP + diphosphate
Cofactor: binds 2 Mg+2 per subunit
Structure:
- belongs to the adenylyl cyclase class-4/guanylyl cyclase family
- contains 2 guanylate cyclase domains
Compartment: membrane
Expression:
- expressed in multiple cells of the lung
- expression highest in airway smooth muscle
General
adenyl cyclase, adenylyl cyclase or adenylate cyclase
glycoprotein
phosphoprotein
transmembrane 12 protein
Properties
SIZE: entity length = 1353 aa
MW = 151 kD
COMPARTMENT: plasma membrane*
CELL: most cell types*
ORGANISM: eukaryote*
MOTIF: cytoplasmic domain {1-117}
transmembrane domain {118-138}
exoplasmic loop {139-141}
transmembrane domain {142-162}
cytoplasmic loop {163-171}
transmembrane domain {172-192}
exoplasmic loop {193-215}
MOTIF: N-glycosylation site {N206}
transmembrane domain {216-235}
cytoplasmic loop {236-241}
transmembrane domain {242-259}
exoplasmic loop {260-280}
transmembrane domain {281-301}
cytoplasmic loop {302-786}
MOTIF: Ser phosphorylation site {S365}
Mg+2-binding site
SITE: 399-399
Mg+2-binding site
SITE: 400-400
Mg+2-binding site
SITE: 443-443
Thr phosphorylation site {T608}
Ser phosphorylation site {S610}
transmembrane domain {787-807}
exoplasmic loop {808-818}
transmembrane domain {819-839}
cytoplasmic loop {840-867}
transmembrane domain {868-888}
exoplasmic loop {889-891}
transmembrane domain {892-912}
cytoplasmic loop {913-920}
transmembrane domain {921-941}
exoplasmic loop {942-975}
MOTIF: N-glycosylation site {N955}
N-glycosylation site {N964}
transmembrane domain {976-996}
cytoplasmic domain {997-1353}
STATE: Inactive
Database Correlations
OMIM 603302
UniProt O60503
Pfam PF00211
Entrez Gene 115
Kegg hsa:115
ENZYME 4.6.1.1
References
UniProt :accession O60503