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adenyl cyclase-3 (ATP pyrophosphate-lyase 3, adenylyl cyclase 3, adenylate cyclase olfactive type, ADCY3)
Function:
- mediates odorant detection (possibly) via modulation of intracellular cAMP concentration
- activated by Ca+2/calmodulin & Gs-alpha[GTP] [2]
ATP 3',5'-cyclic AMP + diphosphate
Cofactor: binds 2 Mg+2 per subunit (putative)
Structure:
- belongs to the adenylyl cyclase class-4/guanylyl cyclase family
- contains 2 guanylate cyclase domains
Compartment: membrane
Expression:
- expressed in brain, heart, kidney, liver, lung, pancreas, placenta, & skeletal muscle
- richest source is the olfactory neuroepithelium
Interactions
molecular events
General
adenyl cyclase, adenylyl cyclase or adenylate cyclase
glycoprotein
transmembrane 12 protein
Properties
SIZE: entity length = 1144 aa
MW = 129 kD
COMPARTMENT: plasma membrane
MOTIF: cytoplasmic domain {1-79}
transmembrane domain {80-100}
exoplasmic loop {101-104}
transmembrane domain {105-125}
cytoplasmic loop {126-138}
transmembrane domain {139-159}
exoplasmic loop {160-172}
transmembrane domain {173-193}
cytoplasmic loop {194-225}
transmembrane domain {226-246}
exoplasmic loop {247-380}
MOTIF: Mg+2-binding site
SITE: 324-324
Mg+2-binding site
SITE: 325-325
Mg+2-binding site
SITE: 368-368
transmembrane domain {381-401}
cytoplasmic loop {402-632}
transmembrane domain {633-653}
exoplasmic loop {654-663}
transmembrane domain {664-684}
cytoplasmic loop {685-707}
transmembrane domain {708-728}
exoplasmic loop {729-753}
MOTIF: N-glycosylation site {N736}
transmembrane domain {754-774}
transmembrane domain {775-795}
MOTIF: cytoplasmic loop {775-774}
exoplasmic loop {796-832}
transmembrane domain {833-853}
cytoplasmic domain {854-1144}
STATE: Inactive
Database Correlations
OMIM 600291
UniProt O60266
Pfam PF00211
Entrez Gene 109
KEGG correlations
ENZYME 4.6.1.1
References
- Bakalyar & Reed Science 250:1403 1990
- Cooper et al
Adenylyl cyclases and the interaction between calcium and
cAMP signalling.
Nature 374:421 1995
PMID: 7700350
- UniProt :accession O60266