adenyl cyclase-2 (ATP pyrophosphate-lyase 2, ADCY2, KIAA1060)

Function: - membrane-bound, calmodulin-insensitive adenylyl cyclase - insensitive to Ca⁺²/calmodulin - stimulated by protein kinase C, Gs-alpha[GTP] & G-beta/gamma (putative) ATP 3',5'-cyclic AMP + diphosphate Cofactor: binds 2 Mg⁺² per subunit (putative) Structure: - belongs to the adenylyl cyclase class-4/guanylyl cyclase family - contains 2 guanylate cyclase domains Compartment: membrane Expression: - expressed in brain - richest source is cerebellum

General

adenyl cyclase, adenylyl cyclase or adenylate cyclase glycoprotein membrane protein

Properties

SIZE: entity length = 1091 aa MW = 124 kD COMPARTMENT: plasma membrane* CELL: most cell types* ORGANISM: eukaryote* MOTIF: cytoplasmic domain {1-45} transmembrane domain {46-66} exoplasmic loop {67-75} transmembrane domain {76-96} cytoplasmic loop {97-107} transmembrane domain {108-128} exoplasmic loop {129-132} transmembrane domain {133-153} cytoplasmic loop {154-158} transmembrane domain {159-179} exoplasmic loop {180-186} transmembrane domain {187-207} cytoplasmic loop {208-601} MOTIF: Mg+2-binding site SITE: 295-295 Mg+2-binding site SITE: 296-296 Mg+2-binding site SITE: 339-339 transmembrane domain {602-622} exoplasmic loop {623-627} transmembrane domain {628-652} cytoplasmic loop {653-679} transmembrane domain {680-701} exoplasmic loop {702-733} MOTIF: N-glycosylation site {N713} N-glycosylation site {N716} transmembrane domain {734-755} cytoplasmic loop {756-762} transmembrane domain {763-780} exoplasmic loop {781-800} transmembrane domain {801-821} cytoplasmic domain {822-1091} STATE: Inactive

Database Correlations

OMIM 103071 UniProt Q08462 PFAM correlations Entrez Gene 108 KEGG correlations ENZYME 4.6.1.1