adenyl cyclase-1 (ADCY1, Ca+2/calmodulin-activated adenyl cyclase)

Function: - calmodulin-sensitive adenylyl cyclase - may be involved in regulatory processes in the central nervous system - may play a role in memory acquisition & learning - activated by Ca⁺²/calmodulin - Gs-alpha[GTP] is only mildly stimulatory [2] - inhibited by G-beta/gamma ATP 3',5'-cyclic AMP + diphosphate Cofactor: binds 2 Mg⁺² per subunit (putative) Structure: - belongs to the adenylyl cyclase class-4/guanylyl cyclase family - contains 2 guanylate cyclase domains Compartment: membrane Expression: - brain, retina & adrenal medulla - richest sources are the dentate gyrus & hippocampus

General

adenyl cyclase, adenylyl cyclase or adenylate cyclase glycoprotein

Properties

SIZE: entity length = 1119 aa MW = 123 kD COMPARTMENT: plasma membrane* CELL: most cell types* ORGANISM: eukaryote* MOTIF: cytoplasmic domain {1-63} transmembrane domain {64-84} exoplasmic loop {85-87} transmembrane domain {88-108} cytoplasmic loop {109-124} transmembrane domain {125-145} exoplasmic loop {146-157} transmembrane domain {158-178} cytoplasmic loop {179-182} transmembrane domain {183-203} exoplasmic loop {204-213} transmembrane domain {214-234} cytoplasmic loop {235-610} MOTIF: Mg+2-binding site SITE: 308-308 Mg+2-binding site SITE: 309-309 Mg+2-binding site SITE: 352-352 calmodulin interaction {493-520} transmembrane domain {611-631} exoplasmic loop {632-634} transmembrane domain {635-655} cytoplasmic loop {656-673} transmembrane domain {674-694} exoplasmic loop {695-724} MOTIF: N-glycosylation site {N704} transmembrane domain {725-745} cytoplasmic loop {746-752} transmembrane domain {753-773} exoplasmic loop {774-774} transmembrane domain {775-794} cytoplasmic domain {795-1119} MOTIF: calmodulin interaction {1024-1047} STATE: Inactive

Database Correlations

OMIM 103072 UniProt Q08828 Pfam PF00211 Entrez Gene 107 Kegg hsa:107 ENZYME 4.6.1.1