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adenylosuccinate synthetase isozyme 2 (IMP-aspartate ligase 2, AdSS 2, AMPSase 2, ADSS, ADSS2)
Function:
- role in the de novo pathway of purine nucleotide biosynthesis
- nucleotide biosynthesis; AMP biosynthesis; AMP from IMP: step 1/2
GTP + IMP + L-aspartate
GDP + phosphate + N(6)-(1,2-dicarboxyethyl)-AMP
Cofactor: binds 1 Mg+2 per subunit (putative)
Structure:
- homodimer (putative)
- belongs to the adenylosuccinate synthetase family
Compartment:
- cytoplasm
- partially associated with particulate fractions
General
ligase or synthetase
Properties
MOTIF: active site
MOTIF: lysine residue
Database Correlations
OMIM 103060
SWISS-PROT correlations
Pfam PF00709
Entrez Gene 159
ENZYME 6.3.4.4
References
UniProt :accession P30520