adenylate kinase isoenzyme 6; ATP-AMP transphosphorylase 6; coilin-interacting nuclear ATPase protein; hCINAP (TAF9, AK6, CINAP, AD-004, CGI-137)

Function: - broad activity as an NMP kinase - AMP & dAMP are the preferred substrates of all tested NMPs, - CMP & dCMP are also good substrates - IMP can be phosphorylated, but to a much lesser extent - adenylate & cytidylate can serve as phosphate acceptors - interacts with COIL (via C-terminus) ATP + AMP = 2 ADP , Kinetic parameters: - KM=75.3 uM for ATP - Vmax=1.27 umol/min/mg enzyme Structure: - belongs to the adenylate kinase family, AK6 subfamily Compartment: - nucleus, nucleoplasm. nucleus, Cajal body - widespread diffuse nucleoplasmic distribution - not detected in nucleoli - detected in Cajal bodies but not in all cells Alternative splicing: named isoforms=3 Notes: - isoform 1 & isoform 2 are produced by the same gene but are translated from different initiation codons & use different reading frames so they display no identity in their protein sequences - this arrangement is conserved in mammals but these proteins are produced by separate genes in non-mammalian species

Properties

SIZE: entity length = 172 aa MW = 20 kD COMPARTMENT: cell nucleus MOTIF: ATP-binding site NAME: ATP-binding site SITE: 10-17

Database Correlations

UniProt Q9Y3D8 Pfam PF00004 Entrez Gene 6880 Kegg hsa:6880 ENZYME 2.7.4.3

References

UniProt :accession Q9Y3D8