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adenosine receptor A3 (ADORA3)
Function:
- receptor for adenosine
- activity mediated by G proteins which inhibit adenylyl cyclase (Gi proteins)
- possible role in reproduction
- phosphorylation on Ser-317 may be crucial for rapid desensitization
Structure:
- belongs to the G-protein coupled receptor 1 family
Compartment:
- cell membrane; multi-pass membrane protein
General
glycoprotein
membrane protein
receptor
Properties
SIZE: entity length = 318 aa
MW = 36 kD
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-14}
MOTIF: N-glycosylation site {N3}
N-glycosylation site {N4}
N-glycosylation site {N12}
transmembrane domain {15-37}
cytoplasmic loop {38-48}
transmembrane domain {49-72}
exoplasmic loop {73-84}
MOTIF: cysteine residue {C83}
MODIFICATION: cysteine residue {C166}
transmembrane domain {85-106}
cytoplasmic loop {107-126}
transmembrane domain {127-148}
exoplasmic loop {149-177}
MOTIF: cysteine residue {C166}
MODIFICATION: cysteine residue {C83}
transmembrane domain {178-198}
cytoplasmic loop {199-231}
transmembrane domain {232-255}
exoplasmic loop {256-261}
transmembrane domain {262-284}
cytoplasmic domain {285-318}
MOTIF: cysteine residue {C303}
MODIFICATION: palmitate
COMPARTMENT: membrane
Ser phosphorylation site {S317}
Database Correlations
OMIM 600445
UniProt P0DMS8
References
- UniProt :accession P0DMS8
- VanDongen AM, Codina J, Olate J, Mattera R, Joho R,
Birnbaumer L, Brown AM.
Newly identified brain potassium channels gated by the guanine
nucleotide binding protein Go.
Science. 1988 Dec 9;242(4884):1433-7.
PMID: 3144040