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adenosine kinase (adenosine 5'-phosphotransferase, ADK)
Function:
- ATP dependent phosphorylation of adenosine & other related nucleoside analogs to monophosphate derivatives
- potential regulator of concentrations of extracellular adenosine & intracellular adenine nucleotides
- urine metabolism; AMP biosynthesis via salvage pathway
- AMP from adenosine: step 1/1
ATP + adenosine ADP + AMP
Cofactor: binds 3 Mg+2 per subunit
Structure:
- monomer
- belongs to the carbohydrate kinase pfkB family
Alternative splicing: named isoforms=2
Expression:
- widely expressed
- highest level in placenta, liver, muscle & kidney
Interactions
molecular events
General
kinase or ATP-phosphotransferase
Properties
SIZE: entity length = 362 aa
MW = 41 kD
MOTIF: Mg+2-binding site
SITE: 49-49
Tyr phosphorylation site {Y77}
Mg+2-binding site
SITE: 147-147
Mg+2-binding site
SITE: 148-148
aspartate residue {D317}
Database Correlations
OMIM 102750
UniProt P55263
Pfam PF00294
Entrez Gene 132
Kegg hsa/hsa00230
ENZYME 2.7.1.20
References
- UniProt :accession P55263
- PMID: 90160191