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adenosine A2B receptor (ADORA2B)
Function:
- receptor for adenosine
- activity of this receptor is mediated by G proteins which activate adenylyl cyclase (Gs protein)
Structure: belongs to the G-protein coupled receptor 1 family
Compartment: cell membrane
General
adenosine A2 receptor
glycoprotein
Properties
SIZE: entity length = 332 aa
MW = 36 kD
COMPARTMENT: synaptic membrane
CELL: neuron
MOTIF: exoplasmic domain {1-8}
transmembrane domain {9-31}
cytoplasmic loop {32-44}
transmembrane domain {45-67}
exoplasmic loop {68-78}
MOTIF: cysteine residue {C78}
MODIFICATION: cysteine residue {C171}
transmembrane domain {79-101}
cytoplasmic loop {102-121}
transmembrane domain {122-144}
exoplasmic loop {145-178}
MOTIF: N-glycosylation site {N153}
N-glycosylation site {N163}
cysteine residue {C171}
MODIFICATION: cysteine residue {C78}
transmembrane domain {179-203}
cytoplasmic loop {204-235}
transmembrane domain {236-259}
exoplasmic loop {260-267}
transmembrane domain {268-291}
cytoplasmic domain {292-332}
MOTIF: cysteine residue {C311}
MODIFICATION: palmitate
COMPARTMENT: membrane
Database Correlations
OMIM 600446
UniProt P29275
Pfam PF00001
Entrez Gene 136
Kegg hsa:136
References
UniProt :accession P29275