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adenosine A2A receptor (ADORA2A, ADORA2)
Function:
- receptor for adenosine
- activity is mediated by G proteins which activate adenylyl cyclase (Gi protein)
Structure: belongs to the G-protein coupled receptor 1 family
Compartment: cell membrane
General
adenosine A2 receptor
glycoprotein
Properties
SIZE: entity length = 412 aa
MW = 45 kD
COMPARTMENT: synaptic membrane
CELL: neuron
MOTIF: exoplasmic domain {1-7}
transmembrane domain {8-30}
cytoplasmic loop {31-43}
transmembrane domain {44-66}
exoplasmic loop {67-77}
MOTIF: cysteine residue {C77}
MODIFICATION: cysteine residue {C166}
transmembrane domain {78-100}
cytoplasmic loop {101-120}
transmembrane domain {121-143}
exoplasmic loop {144-173}
MOTIF: N-glycosylation site {N154}
cysteine residue {C166}
MODIFICATION: cysteine residue {C77}
transmembrane domain {174-198}
cytoplasmic loop {199-234}
transmembrane domain {235-258}
exoplasmic loop {259-266}
transmembrane domain {267-290}
cytoplasmic domain {291-412}
Database Correlations
OMIM 102776
UniProt P29274
Pfam PF00001
Entrez Gene 135
Kegg hsa:135
References
UniProt :accession P29274