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adenosine A1 receptor (ADORA1)
Function:
- receptor for adenosine
- activity is mediated by G proteins which inhibit adenylyl cyclase (Gi proteins)
Structure: belongs to the G-protein coupled receptor 1 family
Compartment: cell membrane
Alternative splicing: named isoforms=2
General
adenosine receptor
glycoprotein
Properties
SIZE: entity length = 326 aa
MW = 37 kD
COMPARTMENT: synaptic membrane
CELL: neuron
MOTIF: exoplasmic domain {1-10}
transmembrane domain {11-33}
cytoplasmic loop {34-46}
transmembrane domain {47-69}
exoplasmic loop {70-80}
MOTIF: cysteine residue {C80}
MODIFICATION: cysteine residue {C169}
transmembrane domain {81-102}
cytoplasmic loop {103-123}
transmembrane domain {124-146}
exoplasmic loop {147-176}
MOTIF: N-glycosylation site {N159}
cysteine residue {C169}
MODIFICATION: cysteine residue {C80}
transmembrane domain {177-201}
cytoplasmic loop {202-235}
transmembrane domain {236-259}
exoplasmic loop {260-267}
transmembrane domain {268-292}
cytoplasmic domain {293-326}
MOTIF: cysteine residue {C309}
MODIFICATION: palmitate
COMPARTMENT: membrane
Database Correlations
OMIM 102775
UniProt P30542
Pfam PF00001
Entrez Gene 134
Kegg hsa:134
References
- UniProt :accession P30542
- VanDongen AM, Codina J, Olate J, Mattera R, Joho R,
Birnbaumer L, Brown AM.
Newly identified brain potassium channels gated by the guanine
nucleotide binding protein Go.
Science. 1988 Dec 9;242(4884):1433-7.
PMID: 3144040