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adenomatous polyposis coli protein 2 (adenomatous polyposis coli protein-like, APC2, APCL)
Function:
- promotes rapid degradation of CTNNB1
- may function as tumor suppressor.
- may function in Wnt signaling
- interacts with PSRC1 (putative)
- interacts with APC, CTNNB1, MAPRE1, MAPRE3, TP53BP2 & possibly with AXIN2
Structure:
- belongs to the adenomatous polyposis coli (APC) family
- contains 6 ARM repeats
Compartment:
- cytoplasm
- Golgi (cytoplasmic side)
- cell membrane (cytoplasmic side)
- associated with actin filaments & the microtubule network
Alternative splicing: named isoforms=3
Expression:
- widely expressed (at protein level)
- specifically expressed in the CNS
- expressed in fetal brain
Related
adenomatous polyposis coli protein (protein APC, APC, DP25)
General
anti-oncoprotein (tumor suppressor protein)
cytoskeletal protein
Properties
SIZE: entity length = 2303 aa
MW = 244 kD
COMPARTMENT: cytoplasm
golgi
MOTIF: coiled coil {8-59}
ARM repeat {302-341}
ARM repeat {479-518}
ARM repeat {522-562}
ARM repeat {566-609}
ARM repeat {615-654}
ARM repeat {657-696}
coiled coil {840-864}
consensus repeat {1058-1077}
serine-rich region {1145-1196}
MOTIF: serine residue (SEVERAL)
consensus repeat {1150-1169}
consensus repeat {1263-1282}
consensus repeat {1391-1410}
proline-rich region
SITE: 1518-1622
MOTIF: proline residue (SEVERAL)
consensus repeat {1568-1587}
proline-rich region
SITE: 1765-1953
MOTIF: proline residue (SEVERAL)
MAPRE1 & MAPRE3 interaction {2067-2144}
Database Correlations
UniProt O95996
PFAM correlations
References
UniProt :accession O95996