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adenine phosphoribosyltransferase (APRT)
Function:
- catalyzes a salvage reaction resulting in the formation of AMP (salvage is energically less costly than de novo synthesis)
- purine metabolism; AMP biosynthesis via salvage pathway
- AMP from adenine: step 1/1
AMP + diphosphate
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
Structure:
- homodimer
- belongs to the purine/pyrimidine phosphoribosyltransferase family
Compartment: cytoplasm
Pathology:
- defects in APRT are the cause of APRT deficiency
Laboratory:
- adenine phosphoribosyltransferase in amniotic fluid cells
- adenine phosphoribosyltransferase in chorionic villus
- adenine phosphoribosyltransferase in erythrocytes
- adenine phosphoribosyltransferase in serum/plasma
- adenine phosphoribosyltransferase in trophoblasts
Specific
cleavage & polyadenylation specificity factor (CPSF) complex
General
phosphoribosyltransferase
Properties
MOTIF: active site
Database Correlations
OMIM 102600
MORBIDMAP 102600
UniProt P07741
Pfam PF00156
Entrez Gene 353
Kegg hsa:353
ENZYME 2.4.2.7
References
- UniProt :accession P07741
- OMIM :accession 102600
- Wikipedia: adenine phosphoribosyltransferase entry
http://en.wikipedia.org/wiki/adenine_phosphoribosyltransferase