A disintegrin & metalloproteinase with thrombospondin type 1 motif (ADAMTS)

Function: - soluble extracellular matrix proteases Structure: - related to ADAM proteases - the metalloprotease & disintegrin domains are flanked by thrombospondin type I (TSP1) repeat

Specific

A disintegrin & metalloproteinase with thrombospondin type 1 motif 1; ADAMTS-1; ADAM-TS 1; ADAM-TS1; METH-1 (ADAMTS1, KIAA1346, METH1) A disintegrin & metalloproteinase with thrombospondin type 1 motif 2; ADAMTS-2; ADAM-TS 2; ADAM-TS2; procollagen I/II amino propeptide-processing enzyme; procollagen I N-proteinase; PC I-NP; procollagen N-endopeptidase; pNPI (ADAMTS2, PCINP, PCPNI) A disintegrin & metalloproteinase with thrombospondin type 1 motif 3; ADAMTS-3; ADAM-TS 3; ADAM-TS3; procollagen II amino propeptide-processing enzyme; procollagen II N-proteinase; PC II-NP (ADAMTS3, KIAA0366) A disintegrin & metalloproteinase with thrombospondin type 1 motif 4; ADAMTS-4; ADAM-TS 4; ADAM-TS4; aggrecanase-1; ADMP-1 (ADAMTS4, KIAA0688, UNQ769/PRO1563) A disintegrin & metalloproteinase with thrombospondin type 1 motif 5; ADAMTS-5; ADAM-TS 5; ADAM-TS5; aggrecanase-2; ADMP-2; A disintegrin & metalloproteinase with thrombospondin motifs 11; ADAMTS-11; ADAM-TS 11 (ADAMTS5, ADAMTS11, ADMP2) A disintegrin & metalloproteinase with thrombospondin type 1 motif 6; ADAMTS-6; ADAM-TS 6; ADAM-TS6; (ADAMTS6) A disintegrin & metalloproteinase with thrombospondin type 1 motif 7; ADAMTS-7; ADAM-TS 7; ADAM-TS7; COMPase (ADAMTS7) A disintegrin & metalloproteinase with thrombospondin type 1 motif 8; ADAMTS-8; ADAM-TS 8; ADAM-TS8; METH-2; METH-8 (ADAMTS8, METH2) A disintegrin & metalloproteinase with thrombospondin type 1 motif 9; ADAMTS-9; ADAM-TS 9; ADAM-TS9 (ADAMTS9, KIAA1312) A disintegrin & metalloproteinase with thrombospondin type 1 motif 10; ADAMTS-10; ADAM-TS 10; ADAM-TS10; (ADAMTS10) A disintegrin & metalloproteinase with thrombospondin type 1 motif 12; ADAMTS-12; ADAM-TS 12; ADAM-TS12; (ADAMTS12) A disintegrin & metalloproteinase with thrombospondin type 1 motif 13; ADAMTS-13; ADAM-TS 13; ADAM-TS13; von Willebrand factor-cleaving protease; vWF-cleaving protease; vWF-CP (ADAMTS13, C9orf8, UNQ6102/PRO20085) A disintegrin & metalloproteinase with thrombospondin type 1 motif 14; ADAMTS-14; ADAM-TS 14; ADAM-TS14 (ADAMTS14) A disintegrin & metalloproteinase with thrombospondin type 1 motif 15; ADAMTS-15; ADAM-TS 15; ADAM-TS15 (ADAMTS15) A disintegrin & metalloproteinase with thrombospondin type 1 motif 16; ADAMTS-16; ADAM-TS 16; ADAM-TS16 (ADAMTS16, KIAA2029) A disintegrin & metalloproteinase with thrombospondin type 1 motif 17; ADAMTS-17; ADAM-TS 17; ADAM-TS17 (ADAMTS17) A disintegrin & metalloproteinase with thrombospondin type 1 motif 18; ADAMTS-18; ADAM-TS 18; ADAM-TS18 (ADAMTS18, ADAMTS21) A disintegrin & metalloproteinase with thrombospondin type 1 motif 19; ADAMTS-19; ADAM-TS 19; ADAM-TS19 (ADAMTS19) A disintegrin & metalloproteinase with thrombospondin type 1 motif 20; ADAMTS-20; ADAM-TS 20; ADAM-TS20 (ADAMTS20)

General

secreted protein zinc metalloprotease

Properties

COMPARTMENT: extracellular compartment MOTIF: disintegrin domain TSP1 module cysteine-rich region

References

- Yong VW et al Metalloproteinases in biology and pathology of the nervous system. Nat Rev Neurosci. 2001 Jul;2(7):502-11. Review. PMID: 11433375