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ADAMTS-like protein 1; ADAMTSL-1; Punctin-1 (ADAMTSL1, ADAMTSR1, C9orf94, UNQ528/PRO1071)

Function: - lacks the metalloprotease & disintegrin-like domains typical of ADAMTS proteases - O-fucosylated by POFUT2 on Ser or Thr - fucosylated repeats can be further glycosylated by addition of a beta-1,3-glucose residue by B3GALTL - fucosylation mediates the efficient secretion of ADAMTSL1 Structure: - C-, N- & O-glycosylated - contains 4 Ig-like C2-type domains - contains 1 PLAC domain - contains 9 TSP type-1 domains Compartment: - secreted, extracellular space, extracellular matrix Alternative splicing: - named isoforms=6 - at least one isomer may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay Expression: - expressed primarily in adult skeletal muscle

Related

A disintegrin & metalloproteinase with thrombospondin type 1 motif (ADAMTS) ADAMTS-like protein 3 (punctin-2, ADAMTSL3, KIAA1233)

General

A disintegrin & metalloproteinase with thrombospondin type 1 motif like protein (ADAMTSL) human longevity protein

Properties

SIZE: entity length = 1762 aa MW = 193 kD COMPARTMENT: extracellular compartment MOTIF: signal sequence {1-28} TSP1 module {33-82} MOTIF: cysteine residue {C45} MODIFICATION: cysteine residue {C76} cysteine residue {C49} MODIFICATION: cysteine residue {C81} cysteine residue {C60} MODIFICATION: cysteine residue {C66} cysteine residue {C66} MODIFICATION: cysteine residue {C60} cysteine residue {C76} MODIFICATION: cysteine residue {C45} cysteine residue {C81} MODIFICATION: cysteine residue {C49} N-glycosylation site {N251} TSP1 module {376-424} TSP1 module {436-493} TSP1 module {522-584} MOTIF: cysteine residue {C534} MODIFICATION: cysteine residue {C578} cysteine residue {C538} MODIFICATION: cysteine residue {C583} cysteine residue {C549} MODIFICATION: cysteine residue {C567} cysteine residue {C567} MODIFICATION: cysteine residue {C549} cysteine residue {C578} MODIFICATION: cysteine residue {C534} cysteine residue {C583} MODIFICATION: cysteine residue {C538} TSP1 module {607-665} TSP1 module {666-729} MOTIF: cysteine residue {C678} MODIFICATION: cysteine residue {C723} cysteine residue {C682} MODIFICATION: cysteine residue {C728} cysteine residue {C693} MODIFICATION: cysteine residue {C712} cysteine residue {C712} MODIFICATION: cysteine residue {C693} cysteine residue {C723} MODIFICATION: cysteine residue {C678} cysteine residue {C728} MODIFICATION: cysteine residue {C682} TSP1 module {788-850} MOTIF: cysteine residue {C800} MODIFICATION: cysteine residue {C844} cysteine residue {C804} MODIFICATION: cysteine residue {C849} cysteine residue {C815} MODIFICATION: cysteine residue {C832} cysteine residue {C832} MODIFICATION: cysteine residue {C815} cysteine residue {C844} MODIFICATION: cysteine residue {C800} cysteine residue {C849} MODIFICATION: cysteine residue {C804} immunoglobulin superfamily domain {861-963} MOTIF: cysteine residue {C899} MODIFICATION: cysteine residue {C947} cysteine residue {C947} MODIFICATION: cysteine residue {C899} N-glycosylation site {N1084} immunoglobulin superfamily domain {1164-1266} MOTIF: cysteine residue {C1202} MODIFICATION: cysteine residue {C1250} cysteine residue {C1250} MODIFICATION: cysteine residue {C1202} immunoglobulin superfamily domain {1286-1369} MOTIF: cysteine residue {C1308} MODIFICATION: cysteine residue {C1353} N-glycosylation site {N1342} cysteine residue {C1353} MODIFICATION: cysteine residue {C1308} immunoglobulin superfamily domain {1395-1485} MOTIF: cysteine residue {C1418} MODIFICATION: cysteine residue {C1469} cysteine residue {C1469} MODIFICATION: cysteine residue {C1418} TSP1 module {1545-1608} TSP1 module {1666-1726} PLAC {1726-1762}

Database Correlations

OMIM 609198 UniProt Q8N6G6 PFAM correlations Entrez Gene 92949 Kegg hsa:92949

References

  1. UniProt :accession Q8N6G6
  2. Gene ID: 92949; ADAMTSL1 ADAMTS-like 1 [ Homo sapiens ] http://www.ncbi.nlm.nih.gov/gene/92949
  3. Wang LW, Leonhard-Melief C, Haltiwanger RS, Apte SS. Post-translational modification of thrombospondin type-1 repeats in ADAMTS-like 1/punctin-1 by C-mannosylation of tryptophan. J Biol Chem. 2009 Oct 30;284(44):30004-15. PMID: 19671700 Free PMC Article