ADA2A-containing complex

Function: - histone acetyltransferase activity on histone H3 & histone H4 Structure: - subunits include: CSRP2BP, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 & DR1

Properties

SUBUNITS: cysteine-rich protein 2-binding protein COMPARTMENT: cytoplasm cell nucleus MOTIF: N-acetyltransferase {638-782} transcriptional adapter 2-like COMPARTMENT: cell nucleus MOTIF: cysteine-rich region {17-45} SANT {70-122} SWIRM {356-443} MOTIF: DNA-binding motif SITE: 426-435 transcriptional adapter 3-like COMPARTMENT: cell nucleus MOTIF: coiled coil {40-69} coiled coil {367-407} MAP3K12 binding inhibitory protein 1 COMPARTMENT: cytoplasm cell nucleus MOTIF: binding site SITE: 172-344 FOR-BINDING-OF: MAP kinse kinase kinase 12 MOTIF: leucine zipper SITE: 271-285 FOR-BINDING-VIA: leucine zipper leucine zipper SITE: 314-329 FOR-BINDING-VIA: leucine zipper WD repeat-containing protein 5 COMPARTMENT: cell nucleus MOTIF: WD repeat {43-82} WD repeat {85-126} MOTIF: aspartate residue {107} WD repeat {128-168} MOTIF: phenylalanine residue {133} WD repeat {169-208} WD repeat {212-253} WD repeat {256-296} MOTIF: phenylalanine residue {263} Ser phosphorylation site {S267} WD repeat {299-333} MOTIF: glutamate residue {322} YEATS domain-containing protein 2 COMPARTMENT: cell nucleus MOTIF: coiled coil {47-80} Ser phosphorylation site {S118} Ser phosphorylation site {S144} YEATS {207-317} Ser phosphorylation site {S447} Ser phosphorylation site {S465} Ser phosphorylation site {S519} glycine-rich region {794-842} Coiled-coil domain-containing protein 101 MOTIF: coiled coil {3-88} DR1 protein COMPARTMENT: cell nucleus MOTIF: nuclear translocation signal {100-103} Ser phosphorylation site {S105} glutamine-rich region {121-168} MOTIF: glutamine residue (SEVERAL)

References

UniProt :accession Q9UGP9

Components

Coiled-coil domain-containing protein 101 (CCDC101) cysteine-rich protein 2-binding protein (CSRP2-binding protein, CRP2BP, CRP2-binding partner, CSRP2BP) MAP3K12 binding inhibitory protein 1 (MAPK upstream kinase-binding inhibitory protein, MUK-binding inhibitory protein, MBIP) protein Dr1; down-regulator of transcription 1; TATA-binding protein-associated phosphoprotein; negative cofactor 2-beta; NC2-beta (DR1) transcriptional adapter 2-like; ADA2-like protein (TADA2L, TADA2A) transcriptional adapter 3-like; ADA3-like protein; ADA3 homolog; hADA3 (TADA3L, ADA3, TADA3) WD repeat-containing protein 5; BMP2-induced 3-kb gene protein (WDR5, BIG3) YEATS domain-containing protein 2 (YEATS2, KIAA1197)