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acyloxyacyl hydrolase (AOAH)
Function:
- removes the secondary (acyloxyacyl-linked) fatty acyl chains from the lipid A region of bacterial lipopolysaccharides
3-(acyloxy)acyl group of bacterial toxin
3-hydroxyacyl group of bacterial toxin + a fatty acid
Structure:
- heterodimer
- both subunits contain a number of Cys that may form disulfide bridges
- contains 1 saposin B-type domain
General
glycoprotein
hydrolase
lipase
membrane protein
Properties
SIZE: entity length = 575 aa
MW = 65 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-23}
Saposin B-type {37-118}
MOTIF: cysteine residue {C41}
MODIFICATION: cysteine residue {C114}
cysteine residue {C44}
MODIFICATION: cysteine residue {C108}
N-glycosylation site {N59}
cysteine residue {C70}
MODIFICATION: cysteine residue {C83}
cysteine residue {C83}
MODIFICATION: cysteine residue {C70}
cysteine residue {C108}
MODIFICATION: cysteine residue {C44}
cysteine residue {C114}
MODIFICATION: cysteine residue {C41}
N-glycosylation site {N207}
serine residue {S263}
N-glycosylation site {N336}
N-glycosylation site {N409}
N-glycosylation site {N466}
Database Correlations
OMIM 102593
UniProt P28039
PFAM correlations
Kegg hsa:313
ENZYME 3.1.1.77
References
UniProt :accession P28039