acylglycerol kinase mitochondrial

Function: - lipid kinase - role in lipid metabolism, glycerolipid metabolism - can phosphorylate both monoacylglycerol & diacylglycerol to form lysophosphatidic acid & phosphatidic acid, respectively - does not phosphorylate sphingosine - overexpression increases formation & secretion of lysophosphatidic acid, resulting in transactivation of EGFR & activation of the downstream MAPK signaling, leading to increased cell growth ATP + acylglycerol ADP + acyl-sn-glycerol 3-phosphate ATP + 1,2-diacylglycerol ADP + 1,2-diacyl- sn-glycerol 3-phosphate Cofactor: Mg⁺² Structure: contains 1 DAGKc domain Compartment: mitochondrial membrane Alternative splicing: named isoforms=2 Expression: - highly expressed in muscle, heart, kidney & brain Pathology: - overexpressed in prostate cancer

General

kinase or ATP-phosphotransferase mitochondrial membrane protein

Properties

SIZE: MW = 47 kD entity length = 422 aa COMPARTMENT: mitochondria MOTIF: DAGKc {62-193}

Database Correlations

UniProt Q53H12 Pfam PF00781 ENZYME correlations

References

UniProt :accession Q53H12