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acute renal failure in malignancy
Etiology:
1) prerenal
a) hypercalcemia
b) gastrointestinal losses during chemotherapy
c) hepatic sinusoidal obstruction syndrome following hematopoietic stem cell transplantation
2) renal
a) acute tubular necrosis
1] cisplatin
2] ifosfamide
b) acute interstitial nephritis
1] lymphoma infiltrates
2] leukemia infiltrates
c) tubular obstruction
1] myeloma cast nephropathy (Ig light chains)
2] tumor lysis syndrome
3] methotrexate
d) thrombotic microangiopathy
1] mitomycin
2] cisplatin & bleomycin
3] gemcitabine
4] cyclosporine
5] hematopoietic stem cell transplantation
3) postrenal
a) bladder outlet obstruction
b) retroperitoneal tumor or lymphadenopathy
c) retroperitoneal fibrosis
4) vascular
a) renal vein thrombus
b) renal vein tumor
Related
tumor lysis syndrome
General
acute renal failure (ARF)
References
- Medical Knowledge Self Assessment Program (MKSAP) 15, 18.
American College of Physicians, Philadelphia 2009, 2018.