activity-regulated cytoskeleton-associated protein (activity-regulated gene 3.1 protein homolog, Arg3.1, ARC/ARG3.1, ARC KIAA0278)

Function: - required for consolidation of synaptic plasticity as well as formation of long-term memory (memory consolidation) - regulates endocytosis of AMPA receptors in response to synaptic activity - required for homeostatic synaptic scaling of AMPA receptors (putative) - interacts with SH3GL1/endophilin-2, SH3GL3/endophilin-3 & DNM2/DYN2 (putative) Structure: belongs to the ARC/ARG3.1 family Compartment: - cytoplasm, cytoskeleton (putative), endosome (putative) acrosome - cell junction, synapse, postsynaptic cell membrane, postsynaptic density, cell projection, dendrite (putative), dendritic spine (putative) - associated with the cell cortex of neuronal soma & dendrites - enriched in postsynaptic density of dendritic spines - associated with the sperm tail (putative)

Properties

SIZE: MW = 45 kD entity length = 396 aa COMPARTMENT: cytoplasm MOTIF: coiled coil {54-78} binding site SITE: 89-100 FOR-BINDING-OF: endophilin-A2 endophilin-A3 binding site SITE: 195-214 FOR-BINDING-OF: dynamin 2

References

UniProt :accession Q7LC44