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activity-dependent neuroprotector homeobox protein; activity-dependent neuroprotective protein (ADNP, ADNP1, KIAA0784)
Function:
- putative transcription factor
- may mediate some of the neuroprotective peptide VIP-associated effects involving normal growth & cancer proliferation
- phosphorylated upon DNA damage, probably by ATM or ATR
Structure:
- contains 9 C2H2-type Zn+2 fingers
- contains 1 homeobox DNA-binding domain
Compartment: nucleus (putative)
Expression:
- widely expressed
- strong expression in heart, skeletal muscle, kidney & placenta
- expressed in cerebellum & cerebral cortex
- not expressed in the colon
- strong increase of expression in colon carcinoma & breast cancer tissues
Notes:
- when isolated from the sequence, neuroprotective peptide provides neuroprotection against the beta-amyloid peptide
General
C2H2 type zinc finger protein
phosphoprotein
transcription factor (TF)
Properties
SIZE: entity length = 1102 aa
MW = 124 kD
COMPARTMENT: cell nucleus
MOTIF: Zn finger C2H2-type
SITE: 74-97
EFFECTOR-BOUND: Zn+2
Ser phosphorylation site {S98}
Zn finger C2H2-type
SITE: 107-129
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 165-188
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 221-244
EFFECTOR-BOUND: Zn+2
Neuroprotective peptide (NAP) {354-361}
Ser phosphorylation site {S409}
Ser phosphorylation site {S413}
Zn finger C2H2-type
SITE: 447-469
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 489-510
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 512-535
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 622-647
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 662-686
EFFECTOR-BOUND: Zn+2
Ser phosphorylation site {S709}
Ser phosphorylation site {S736}
homeodomain
SITE: 754-814
Ser phosphorylation site {S876}
Ser phosphorylation site {S878}
Ser phosphorylation site {S921}
Ser phosphorylation site {S953}
Ser phosphorylation site {S955}
Ser phosphorylation site {S970}
Ser phosphorylation site {S982}
Database Correlations
OMIM 611386
UniProt Q9H2P0
Pfam PF00046
Entrez Gene 23394
Kegg hsa:23394
References
UniProt :accession Q9H2P0