mediator of RNA polymerase II transcription subunit 17; activator-recruited cofactor 77 kD component; ARC77; cofactor required for Sp1 transcriptional activation subunit 6; CRSP complex subunit 6; mediator complex subunit 17; thyroid hormone receptor-associated protein complex 80 kD component; trap80; transcriptional coactivator CRSP77; vitamin D3 receptor-interacting protein complex 80 kD component; DRIP80 (MED17, ARC77, CRSP6, DRIP77, DRIP80, TRAP80)

Function: - component of the mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase 2- dependent genes - phosphorylated upon DNA damage, probably by ATM or ATR - interacts with GATA1 & PPARG (putative) - interacts with STAT2 Structure: - belongs to the mediator complex subunit 17 family Compartment: nucleus (probable) Alternative splicing: named isoforms=2 Expression: ubiquitous

General

phosphoprotein transcription factor (TF)

Properties

SIZE: entity length = 651 aa MW = 73 kD COMPARTMENT: cell nucleus MOTIF: Ser phosphorylation site {S37} Ser phosphorylation site {S50} Ser phosphorylation site {S53} Ser phosphorylation site {S55} Ser phosphorylation site {S75} Ser phosphorylation site {S76} Thr phosphorylation site {T143} Ser phosphorylation site {S185}

Database Correlations

OMIM 603810 UniProt Q9NVC6 Pfam PF10156 Entrez Gene 9440 Kegg hsa:9440

References

UniProt :accession Q9NVC6