mediator of RNA polymerase II transcription subunit 26; activator-recruited cofactor 70 kD component; ARC70; cofactor required for Sp1 transcriptional activation subunit 7; CRSP complex subunit 7; mediator complex subunit 26; transcriptional coactivator CRSP70 (MED26, ARC70, CRSP7)

Function: - component of the mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase 2- dependent genes Structure: - belongs to the mediator complex subunit 26 family - contains 1 TFIIS N-terminal domain Compartment: nucleus (probable) Alternative splicing: named isoforms=2

General

phosphoprotein transcription factor (TF)

Properties

SIZE: entity length = 600 aa MW = 65 kD COMPARTMENT: cell nucleus MOTIF: TFIIS N-terminal {10-87} proline-rich region SITE: 228-325 MOTIF: proline residue (SEVERAL) Ser phosphorylation site {S314} Ser phosphorylation site {S337} Ser phosphorylation site {S361} Ser phosphorylation site {S447}

Database Correlations

OMIM 605043 UniProt O95402 Pfam PF08711 Entrez Gene 9441 Kegg hsa:9441

References

UniProt :accession O95402